Article
A study of the interactions between an IgG-binding domain based on the B domain of staphylococcal protein A and rabbit IgG.
Molecular biotechnology - 1 Aug 1998
Brown N L, Bottomley S P, Scawen M D, Gore M G
Abstract excerpt
The nonantigenic interaction between a recombinant immunoglobulin G (IgG)-binding protein based on the B domain of Protein A from Staphylococcus aureus (termed SpA1) and the Fc fragment of rabbit IgG has been investigated. The contribution to binding of four putative hydrogen bond contacts between SpA1 and IgG-Fc were examined by the individual substitution of the residues in SpA1 involved in these interactions...
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