A study of the interactions between an IgG-binding domain based on the B domain of staphylococcal protein A and rabbit IgG.

doi:10.1007/BF02745859

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Article

A study of the interactions between an IgG-binding domain based on the B domain of staphylococcal protein A and rabbit IgG.

Molecular biotechnology - 1 Aug 1998

Brown N L, Bottomley S P, Scawen M D, Gore M G

Abstract excerpt

The nonantigenic interaction between a recombinant immunoglobulin G (IgG)-binding protein based on the B domain of Protein A from Staphylococcus aureus (termed SpA1) and the Fc fragment of rabbit IgG has been investigated. The contribution to binding of four putative hydrogen bond contacts betwee...

Topics

Animals
Binding Sites
Binding, Competitive
Chromatography, Affinity
Circular Dichroism
Enzyme-Linked Immunosorbent Assay
Histidine
Humans
Hydrogen Bonding
Immunoglobulin Fc Fragments
Immunoglobulin G
Mutagenesis, Site-Directed
Mutation
Protein Folding
Rabbits
Recombinant Proteins
Staphylococcal Protein A

Source

Open in PubMed

Identifiers

PMID: 9779419
DOI: 10.1007/BF02745859

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9779419-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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