Article
Heartbroken is a specific downstream mediator of FGF receptor signalling in Drosophila.
Development (Cambridge, England) - 1 Nov 1998
Michelson A M, Gisselbrecht S, Buff E, Skeath J B
Abstract excerpt
Drosophila possesses two FGF receptors which are encoded by the heartless and breathless genes. HEARTLESS is essential for early migration and patterning of the embryonic mesoderm, while BREATHLESS is required for proper branching of the tracheal system. We have identified a new gene, heartbroken...
Topics
- Animals
- Body Patterning
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Movement
- Drosophila
- Drosophila Proteins
- Enzyme Activation
- ErbB Receptors
- Genes, Insect
- Mesoderm
- Models, Biological
- Phenotype
- Protein Kinases
- Protein-Tyrosine Kinases
- Receptors, Fibroblast Growth Factor
- Receptors, Invertebrate Peptide
- Signal Transduction
- Suppression, Genetic