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Article

Heartbroken is a specific downstream mediator of FGF receptor signalling in Drosophila.

Development (Cambridge, England) - 1 Nov 1998

Michelson A M, Gisselbrecht S, Buff E, Skeath J B

Abstract excerpt

Drosophila possesses two FGF receptors which are encoded by the heartless and breathless genes. HEARTLESS is essential for early migration and patterning of the embryonic mesoderm, while BREATHLESS is required for proper branching of the tracheal system. We have identified a new gene, heartbroken, that participates in the signalling pathways of both FGF receptors. Mutations in heartbroken are associated with...

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Identifiers

PMID: 9778498
DOI: 10.1242/dev.125.22.4379

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Heartbroken is a specific downstream mediator of FGF receptor signalling in Drosophila.PMID 9778498Read ↗

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