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Article

The role of oncostatin M in animal and human connective tissue collagen turnover and its localization within the rheumatoid joint.

Arthritis and rheumatism - 1 Oct 1998

Cawston T E, Curry V A, Summers C A, Clark I M, Riley G P, Life P F, Spaull J R, Goldring M B, Koshy P J, Rowan A D, Shingleton W D

Abstract excerpt

OBJECTIVE: To study the interaction of interleukin-1alpha (IL-1alpha) and oncostatin M (OSM) in promoting cartilage collagen destruction. METHODS: Bovine, porcine, and human cartilage and human chondrocytes were studied in culture. The levels of collagenase (matrix metalloproteinase 1 [MMP-1]) and tissue inhibitor of metalloproteinases 1 (TIMP-1) were measured by bioassay and enzyme-linked immunosorbent assay...

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Source

Identifiers

PMID: 9778217
DOI: 10.1002/1529-0131(199810)41:10<1760::AID-ART8>3.0.CO;2-M

Genes

OSM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The role of oncostatin M in animal and human connective tissue collagen turnover and its localization within the rheumatoid joint.PMID 9778217Read ↗

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Oncostatin M Modulates Fibroblast Function via Signal Transducers and Activators of Transcription Proteins–3Semantic proximity Read ↗

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Osteoblasts from the sclerotic subchondral bone downregulate aggrecan but upregulate metalloproteinases expression by chondrocytes. This effect is mimicked by interleukin-6, -1beta and oncostatin M pre-treated non-sclerotic osteoblasts.Semantic proximity Read ↗

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