Article
The role of oncostatin M in animal and human connective tissue collagen turnover and its localization within the rheumatoid joint.
Arthritis and rheumatism - 1 Oct 1998
Cawston T E, Curry V A, Summers C A, Clark I M, Riley G P, Life P F, Spaull J R, Goldring M B, Koshy P J, Rowan A D, Shingleton W D
Abstract excerpt
OBJECTIVE: To study the interaction of interleukin-1alpha (IL-1alpha) and oncostatin M (OSM) in promoting cartilage collagen destruction. METHODS: Bovine, porcine, and human cartilage and human chondrocytes were studied in culture. The levels of collagenase (matrix metalloproteinase 1 [MMP-1]) an...
Topics
- Animals
- Arthritis, Rheumatoid
- Blotting, Northern
- Blotting, Western
- Cartilage, Articular
- Cattle
- Chondrocytes
- Collagen
- Collagenases
- Connective Tissue
- Cytokines
- Growth Inhibitors
- Humans
- Interleukin-1