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Article

Oncostatin M Induces a Pro-inflammatory Phenotype in Intestinal Subepithelial Myofibroblasts.

Inflammatory bowel diseases - 4 Nov 2024

Kokkotis Georgios, Filidou Eirini, Tarapatzi Gesthimani, Spathakis Michail, Kandilogiannakis Leonidas, Dovrolis Nikolas, Arvanitidis Konstantinos, Drygiannakis Ioannis, Valatas Vassilis, Vradelis Stergios, Manolopoulos Vangelis G, Paspaliaris Vasilis, Kolios George, Bamias Giorgos

Abstract excerpt

BACKGROUND: Oncostatin-M (OSM) is associated with antitumor necrosis factor (anti-TNF)-α resistance in inflammatory bowel disease (IBD) and fibrosis in inflammatory diseases. We studied the expression of OSM and its receptors (OSMR, gp130) on intestinal subepithelial myofibroblasts (SEMFs) and the effect of OSM stimulation on SEMFs. METHODS: The mRNA and protein expression of OSM, OSMR, gp130, and several...

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PMID: 38717842
DOI: 10.1093/ibd/izae098

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