Article
Adenoviral transfer of murine oncostatin M elicits periosteal bone apposition in knee joints of mice, despite synovial inflammation and up-regulated expression of interleukin-6 and receptor activator of nuclear factor-kappa B ligand.
The American journal of pathology - 1 May 2002
de Hooge Alfons S K, van de Loo Fons A J, Bennink Miranda B, de Jong Diana S, Arntz Onno J, Lubberts Erik, Richards Carl D, vandDen Berg Wim B
Abstract excerpt
Oncostatin M (OSM) has been described as a bone-remodeling factor either stimulating osteoblast activity or osteoclast formation in vitro. To elucidate the in vivo effect of OSM on bone remodeling, we injected an adenoviral vector encoding murine OSM in knee joints of mice. OSM strongly induced interleukin (IL)-6 gene expression, a known mediator of osteoclast development. We investigated the OSM effect in...
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