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Article

Human mesenchymal stem cell derived osteoblasts degrade organic bone matrix in vitro by matrix metalloproteinases.

Matrix biology : journal of the International Society for Matrix Biology - 1 Sept 2005

Parikka Vilhelmiina, Väänänen Anu, Risteli Juha, Salo Tuula, Sorsa Timo, Väänänen H Kalervo, Lehenkari Petri

Abstract excerpt

Some recent studies have suggested that cells of mesenchymal origin might participate in the organic bone matrix dissolution. In the present study, collagen synthesis and degradation by human mesenchymal stem cell (MSC) derived cells were studied at early stage of osteoblast differentiation using a special two-stage in vitro culture model. In this model, cells were cultured on bovine bone slices, which were first...

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PMID: 16098718
DOI: 10.1016/j.matbio.2005.06.009

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MSC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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