Article
Strong association between DQA1/DQB1 genotype and early-onset IDDM in Chinese: the association is with alleles rather than specific residues.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics - 1 Aug 1998
Chang Y W, Lam K S, Hawkins B R
Abstract excerpt
We report on the role of HLA-DQA1 and DQB1 alleles in determining susceptibility to insulin-dependent diabetes mellitus (IDDM) in Hong Kong Chinese and investigate whether these alleles affect the age of onset of the disease. We studied 76 unrelated Chinese patients and 250 controls. There was no...
Topics
- Adult
- Alleles
- Asian People
- Case-Control Studies
- China
- Diabetes Mellitus, Type 1
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- HLA-DQ Antigens
- HLA-DQ alpha-Chains
- HLA-DQ beta-Chains
- Hong Kong
- Humans
- Male
- Middle Aged