Article
Heregulin inhibits proliferation via ERKs and phosphatidyl-inositol 3-kinase activation but regulates urokinase plasminogen activator independently of these pathways in metastatic mammary tumor cells.
International journal of cancer - 20 Aug 2002
Puricelli Lydia, Proietti Cecilia J, Proiettii Cecilia J, Labriola Leticia, Salatino Mariana, Balañá María E, Aguirre Ghiso Julio, Lupu Ruth, Pignataro Omar P, Charreau Eduardo H, Bal de Kier Joffé Elisa, Elizalde Patricia V
Abstract excerpt
Heregulin (HRG) and type I receptor tyrosine kinase (RTK) expression was investigated in the highly invasive and metastatic LM3 cell line, our previously described model of metastasis for mammary cancer (Bal de Kier Joffe et al. [1986] Invasion Metastasis 6:302-12; Urtreger et al. [1997] Int J Oncol 11:489-96). Although LM3 cells do not express HRG, they exhibit high levels of ErbB-2 and ErbB-3 as well as...
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