Article
Inhibitors of transcription, proteasome inhibitors, and DNA-damaging drugs differentially affect feedback of p53 degradation.
Experimental cell research - 10 Oct 1998
An W G, Chuman Y, Fojo T, Blagosklonny M V
Abstract excerpt
Mutations of the p53 gene are the most common abnormalities in human cancer. In contrast to mutant p53, wild-type (wt) p53 protein is present at low levels due to rapid degradation by proteasome. We demonstrated that wt p53 protein stabilization following DNA damage or proteasome inhibition did n...
Topics
- Cysteine Endopeptidases
- Cysteine Proteinase Inhibitors
- DNA Damage
- DNA, Neoplasm
- Down-Regulation
- Feedback
- Female
- Humans
- Male
- Multienzyme Complexes
- Mutation
- Proteasome Endopeptidase Complex
- Protein Conformation
- Transcription, Genetic
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53