Article
Systematic mutation screening of the pro-opiomelanocortin gene: identification of several genetic variants including three different insertions, one nonsense and two missense point mutations in probands of different weight extremes.
The Journal of clinical endocrinology and metabolism - 1 Oct 1998
Hinney A, Becker I, Heibült O, Nottebom K, Schmidt A, Ziegler A, Mayer H, Siegfried W, Blum W F, Remschmidt H, Hebebrand J
Abstract excerpt
Pro-opiomelanocortin (POMC) is the precursor of melanocortins (adrenocorticotropin: ACTH, beta-endorphin, beta-lipotropin: beta-LPH, corticotropin like intermediate peptide, alpha-, beta- and gamma-melanocyte-stimulating hormone: alpha-, beta- and gamma-MSH) some of which act in the brain to redu...
Topics
- Adolescent
- Adult
- Anorexia Nervosa
- Body Weight
- Child
- DNA Transposable Elements
- Female
- Genetic Testing
- Genetic Variation
- Humans
- Male
- Mutation
- Obesity
- Point Mutation