Article
A constitutively activated mutant of galphaq down-regulates EP-cadherin expression and decreases adhesion between ectodermal cells at gastrulation.
Mechanisms of development - 1 Aug 1998
Rizzoti K, Paquereau L, Shaw A, Knibiehler B, Audigier Y
Abstract excerpt
We have examined the expression and function of the heterotrimeric GTP-binding protein Gq during early Xenopus embryogenesis. Abundant XGalphaq transcripts were detected in oocytes and early embryos by Northern blot analysis. In situ hybridization revealed that these transcripts are confined to t...
Topics
- Animals
- Cadherins
- Cell Adhesion
- Down-Regulation
- Ectoderm
- Embryo, Nonmammalian
- GTP-Binding Proteins
- Gastrula
- Gene Expression Regulation, Developmental
- Microinjections
- Mutation
- Phenotype
- RNA, Messenger
- Xenopus Proteins
- Xenopus laevis