Article
Mutation analysis of the WT1 gene in myelodysplastic syndromes.
Japanese journal of cancer research : Gann - 1 Aug 1998
Hosoya N, Miyagawa K, Mitani K, Yazaki Y, Hirai H
Abstract excerpt
The WT1 tumor suppressor gene was examined for mutations in a panel of 44 patients with myelodysplastic syndromes (MDS) including acute myelogenous leukemias (AML) secondary to MDS, using polymerase chain reaction single-strand conformation polymorphism (PCR-SSCP) analysis and sequencing analysis...
Topics
- Amino Acid Sequence
- Base Sequence
- DNA Mutational Analysis
- DNA-Binding Proteins
- Disease Progression
- Exons
- Genes, Wilms Tumor
- Humans
- Leukemia, Myeloid, Acute
- Mutation
- Myelodysplastic Syndromes
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Polymorphism, Single-Stranded Conformational
- Sequence Homology, Amino Acid
- Sequence Homology, Nucleic Acid
- Transcription Factors
- WT1 Proteins