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Article

Mutational analysis of the "turn" of helix clamp motif of HIV-1 reverse transcriptase.

Biochemical and biophysical research communications - 19 Dec 2008

Wang Yong-Xiang, Zhang Hao-Jie, Xu Jing, Zheng Bo-Jian, Wen Yu-Mei

Abstract excerpt

Helix clamp motifs of polymerases possessing the helix-turn-helix secondary structure are crucial for their polymerase activity by binding to the nucleic acid template/primer via the alpha helices. To study the functions of turn in helix clamp motif of human immunodeficiency virus (HIV)-1 RT, clones with turn mutants at rt271-274 of HIV-1 RT were generated and studied by one cycle infection assay. Mutants rtY271A...

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Identifiers

PMID: 18976635
DOI: 10.1016/j.bbrc.2008.10.106

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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