Article
Cell surface trafficking of Fas: a rapid mechanism of p53-mediated apoptosis.
Science (New York, N.Y.) - 9 Oct 1998
Bennett M, Macdonald K, Chan S W, Luzio J P, Simari R, Weissberg P
Abstract excerpt
p53 acts as a tumor suppressor by inducing both growth arrest and apoptosis. p53-induced apoptosis can occur without new RNA synthesis through an unknown mechanism. In human vascular smooth muscle cells, p53 activation transiently increased surface Fas (CD95) expression by transport from the Golg...
Topics
- Adaptor Proteins, Signal Transducing
- Animals
- Apoptosis
- Brefeldin A
- Carrier Proteins
- Cell Membrane
- Cells, Cultured
- Enzyme Inhibitors
- Etoposide
- Fas Ligand Protein
- Fas-Associated Death Domain Protein
- Golgi Apparatus
- Humans
- Membrane Glycoproteins
- Mice
- Muscle, Smooth, Vascular
- Mutation
- Protein Synthesis Inhibitors