Article
Coupling endoplasmic reticulum stress to the cell death program. An Apaf-1-independent intrinsic pathway.
The Journal of biological chemistry - 14 Jun 2002
Rao Rammohan V, Castro-Obregon Susana, Frankowski Harald, Schuler Martin, Stoka Veronica, del Rio Gabriel, Bredesen Dale E, Ellerby H Michael
Abstract excerpt
Accumulation of misfolded proteins and alterations in Ca2+ homeostasis in the endoplasmic reticulum (ER) causes ER stress and leads to cell death. However, the signal-transducing events that connect ER stress to cell death pathways are incompletely understood. To discern the pathway by which ER stress-induced cell death proceeds, we performed studies on Apaf-1(-/-) (null) fibroblasts that are known to be...
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