Article
Involvement of multiple cis elements in basal- and alpha-adrenergic agonist-inducible atrial natriuretic factor transcription. Roles for serum response elements and an SP-1-like element.
Circulation research - 1 Dec 1995
Sprenkle A B, Murray S F, Glembotski C C
Abstract excerpt
In the present study, cis elements in the 5'-flanking sequence (FS) of the rat atrial natriuretic factor (ANF) gene involved in regulating basal and alpha 1-adrenergic-inducible transcription were investigated. Truncation analyses using ANF-luciferase reporter constructs transfected into primary...
Topics
- Adrenergic alpha-Agonists
- Animals
- Atrial Natriuretic Factor
- Base Sequence
- Cells, Cultured
- DNA-Binding Proteins
- Electrophoresis
- Molecular Sequence Data
- Mutation
- Myocardium
- Nuclear Proteins
- Oligonucleotide Probes
- Protein Binding
- Rats
- Serum Response Factor
- Transcription Factors
- Transcription, Genetic