Article
Conversion of a beta-strand to an alpha-helix induced by a single-site mutation observed in the crystal structure of Fis mutant Pro26Ala.
Protein science : a publication of the Protein Society - 1 Sept 1998
Yang W Z, Ko T P, Corselli L, Johnson R C, Yuan H S
Abstract excerpt
The conversion from an alpha-helix to a beta-strand has received extensive attention since this structural change may induce many amyloidogenic proteins to self-assemble into fibrils and cause fatal diseases. Here we report the conversion of a peptide segment from a beta-strand to an alpha-helix...
Topics
- Amino Acid Sequence
- Bacterial Proteins
- Carrier Proteins
- Crystallography, X-Ray
- Dimerization
- Disulfides
- Escherichia coli
- Escherichia coli Proteins
- Factor For Inversion Stimulation Protein
- Integration Host Factors
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Protein Structure, Secondary