Article
Disrupted collagen architecture in the crystal structure of a triple-helical peptide with a Gly-->Ala substitution.
Connective tissue research - 1 Jan 1996
Bella J, Brodsky B, Berman H M
Abstract excerpt
The crystal structure of the collagen-based peptide (Pro-Hyp-Gly)4-Pro-Hyp-Ala-(Pro-Hyp-Gly)5 has provided for the first time a highly detailed picture of the architectural elements that come into play in the collagen triple helix. The center of the molecule, which harbors a Gly-->Ala substitution, shows subtle conformational changes that result in a local untwisting of the triple helix. The characteristic...
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