Reinnervation of Motor Endplates and Increased Muscle Fiber Size after Human Insulin-Like Growth Factor I Gene Transfer into the Paralyzed Larynx

Abstract excerpt

Current surgical strategies for the treatment of laryngeal paralysis are limited by the muscle atrophy associated with denervation. Moreover, attempts at reinnervation have not effected significant change in surgical outcome. To address this clinical problem, we have developed a rat laryngeal paralysis model to study novel gene transfer strategies. Using this model, the human insulin-like growth factor I (hIGF-I)...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Muscle Physiology and Disorders
• Share to Neurogenetic and Muscular Disorders Research
• Share to Voice and Speech Disorders