Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Timed GDNF gene therapy using an immune-evasive gene switch promotes long distance axon regeneration

14 Dec 2018

Abstract excerpt

Neurosurgical repair in patients with proximal nerve lesions results in unsatisfactory recovery of function. Gene therapy for neurotrophic factors is a powerful strategy to promote axon regeneration. Glial cell line-derived neurotrophic factor (GDNF) gene therapy promotes motor neuron survival and axon outgrowth; however, uncontrolled delivery of GDNF results in axon entrapment. We report that time-restricted...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Nerve injury and regeneration
Share to Neurogenesis and neuroplasticity mechanisms
Share to Tendon Structure and Treatment

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30649249
DOI: 10.1093/brain/awy340

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Timed GDNF gene therapy using an immune-evasive gene switch promotes long distance axon regenerationPMID 30649249Read ↗

GDNF gene delivery to injured adult CNS motor neurons promotes axonal growth, expression of the trophic neuropeptide CGRP, and cellular protection.Semantic proximity Read ↗

Gene therapy for axon regenerationSemantic proximity Read ↗

Nerve growth factor-hypersecreting Schwann cell grafts augment and guide spinal cord axonal growth and remyelinate central nervous system axons in a phenotypically appropriate manner that correlates with expression of L1.Semantic proximity Read ↗

Brief Electrical Stimulation Ameliorates Poor Recovery after Surgical Repair of Injured Peripheral NervesSemantic proximity Read ↗

Derived motor neurons transplantation promotes nerve regeneration in a rodent model of a chronically denervated nerve through delayed adoption of a chronic denervation phenotypeSemantic proximity Read ↗

In Transected Nerves, Distal Repair Schwann Cells at the Injury Site Direct and Accelerate Axonal Regrowth.Semantic proximity Read ↗

Axonal neuregulin 1 is a rate limiting but not essential factor for nerve remyelination.Semantic proximity Read ↗

Increased Survival and Function of SOD1 Mice After Glial Cell-Derived Neurotrophic Factor Gene TherapySemantic proximity Read ↗

Krüppel-like Factor 7 engineered for transcriptional activation promotes axon regeneration in the adult corticospinal tract.Semantic proximity Read ↗

Glial cell line-derived neurotrophic factor promotes increased phenotypic marker expression in femoral sensory and motor-derived Schwann cell cultures.Semantic proximity Read ↗

Transplants of Fibroblasts Genetically Modified to Express BDNF Promote Regeneration of Adult Rat Rubrospinal Axons and Recovery of Forelimb FunctionSemantic proximity Read ↗

Motor Learning Promotes Remyelination via New and Surviving OligodendrocytesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.