Article
Familial eosinophilia maps to the cytokine gene cluster on human chromosomal region 5q31-q33.
American journal of human genetics - 1 Oct 1998
Rioux J D, Stone V A, Daly M J, Cargill M, Green T, Nguyen H, Nutman T, Zimmerman P A, Tucker M A, Hudson T, Goldstein A M, Lander E, Lin A Y
Abstract excerpt
Familial eosinophilia (FE) is an autosomal dominant disorder characterized by peripheral hypereosinophilia of unidentifiable cause with or without other organ involvement. To localize the gene for FE, we performed a genomewide search in a large U.S. kindred, using 312 different polymorphic marker...
Topics
- Adolescent
- Adult
- Aged
- Child
- Child, Preschool
- Chromosome Mapping
- Chromosomes, Human, Pair 5
- Cytokines
- Eosinophilia
- Female
- Genetic Testing
- Genotype
- Granulocyte-Macrophage Colony-Stimulating Factor
- Humans