Article
Evidence for stabilizing selection on codon usage in chromosomal rearrangements of Drosophila pseudoobscura.
G3 (Bethesda, Md.) - 17 Oct 2014
Fuller Zachary L, Haynes Gwilym D, Zhu Dianhui, Batterton Matthew, Chao Hsu, Dugan Shannon, Javaid Mehwish, Jayaseelan Joy C, Lee Sandra, Li Mingmei, Ongeri Fiona, Qi Sulan, Han Yi, Doddapaneni Harshavardhan, Richards Stephen, Schaeffer Stephen W
Abstract excerpt
There has been a renewed interest in investigating the role of stabilizing selection acting on genome-wide traits such as codon usage bias. Codon bias, when synonymous codons are used at unequal frequencies, occurs in a wide variety of taxa. Standard evolutionary models explain the maintenance of codon bias through a balance of genetic drift, mutation and weak purifying selection. The efficacy of selection is...
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