Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The effects of mutation and natural selection on codon bias in the genes of Drosophila.

Genetics - 1 Aug 1994

Kliman R M, Hey J

Abstract excerpt

Codon bias varies widely among the loci of Drosophila melanogaster, and some of this diversity has been explained by variation in the strength of natural selection. A study of correlations between intron and coding region base composition shows that variation in mutation pattern also contributes to codon bias variation. This finding is corroborated by an analysis of variance (ANOVA), which shows a tendency for...

Topics

Animals
Base Composition
Codon
Drosophila melanogaster
Exons
Genes, Insect
Introns
Mutation
Selection, Genetic

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 7982559
DOI: 10.1093/genetics/137.4.1049
PMCID: PMC1206052

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7982559-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The effects of mutation and natural selection on codon bias in the genes of Drosophila.PMID 7982559Read ↗

Mutation pressure, natural selection, and the evolution of base composition in Drosophila.Semantic proximity Read ↗

Variable strength of translational selection among 12 Drosophila species.Semantic proximity Read ↗

Patterns of base composition within the genes of Drosophila melanogaster.Semantic proximity Read ↗

Codon usage in twelve species of Drosophila.Semantic proximity Read ↗

GC-biased segregation of noncoding polymorphisms in Drosophila.Semantic proximity Read ↗

Variation in the Intensity of Selection on Codon Bias over Time Causes Contrasting Patterns of Base Composition Evolution in Drosophila.Semantic proximity Read ↗

Switch in codon bias and increased rates of amino acid substitution in the Drosophila saltans species group.Semantic proximity Read ↗

The correlation between synonymous and nonsynonymous substitutions in Drosophila: mutation, selection or relaxed constraints?Semantic proximity Read ↗

Strong evidence for lineage and sequence specificity of substitution rates and patterns in Drosophila.Semantic proximity Read ↗

Codon bias evolution in Drosophila. Population genetics of mutation-selection drift.Semantic proximity Read ↗

Patterns of mutation and selection at synonymous sites in Drosophila.Semantic proximity Read ↗

Reduced selection for codon usage bias in Drosophila miranda.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.