Article
An association of the polymorphic repeat of tetranucleotide (TCAT) in the first intron of the human tyrosine hydroxylase gene with schizophrenia in a Japanese sample.
Journal of neural transmission (Vienna, Austria : 1996) - 1 Jan 2001
Kurumaji A, Kuroda T, Yamada K, Yoshikawa T, Toru M
Abstract excerpt
Tyrosine hydroxylase (TH) is the rate limiting enzyme in the synthesis of dopamine and norepinephrine. A polymorphic repeat of the tetranucleotide (TCAT) in the first intron of the TH gene may behave as a regulatory element for the gene expression. Allelic fragments of the tandem repeat were typed by a PCR-based process with a pair of primers specific for the polymorphic sequence. The association between the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
