TOM1p, a yeast hect-domain protein which mediates transcriptional regulation through the ADA/SAGA coactivator complexes.

doi:10.1006/jmbi.1998.2036

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Article

TOM1p, a yeast hect-domain protein which mediates transcriptional regulation through the ADA/SAGA coactivator complexes.

Journal of molecular biology - 9 Oct 1998

Saleh A, Collart M, Martens J A, Genereaux J, Allard S, Cote J, Brandl C J

Abstract excerpt

The hect-domain has been characterized as a conserved feature of a group of E3 ubiquitin ligases. Here we show that the yeast hect-domain protein TOM1p regulates transcriptional activation through effects on the ADA transcriptional coactivator proteins. Null mutations of tom1 result in similar de...

Topics

Acetyltransferases
Alcohol Dehydrogenase
Cysteine
DNA-Binding Proteins
Endopeptidases
Fungal Proteins
Gene Expression Regulation, Fungal
Histone Acetyltransferases
Homeodomain Proteins
Hydro-Lyases
Mutation
Precipitin Tests
Promoter Regions, Genetic
Recombinant Proteins

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Open in PubMed

Identifiers

PMID: 9753545
DOI: 10.1006/jmbi.1998.2036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9753545-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Repressor Proteins

Saccharomyces cerevisiae Proteins

TATA-Box Binding Protein

Transcription Factors