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The final obstacle to successful pre‐clinical xenotransplantation?

25 Jun 2020

Abstract excerpt

Genetically engineered pigs are now available for xenotransplantation in which all three known carbohydrate xenoantigens, against which humans have natural antibodies, have been deleted (triple-knockout [TKO] pigs). Furthermore, multiple human transgenes have been expressed in the TKO pigs, all of which are aimed at protecting the cells from the human immune response. Many human sera demonstrate no or minimal...

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PMID: 32585053
DOI: 10.1111/xen.12596

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