Article
Absence of Bruton's tyrosine kinase (Btk) mutations in patients with acute myeloid leukaemia.
British journal of haematology - 1 Sept 1998
Ritis K, Speletas M, Tsironidou V, Pardali E, Kanariou M, Moschese V, Orlandi P, Skordala M, Rossi P, Kartalis G, Bourikas G, Sideras P
Abstract excerpt
Bruton's tyrosine kinase (Btk) is a non-receptor protein tyrosine kinase (PTK) that is expressed in all haemopoietic lineages except mature T cells and plasma cells. Despite the broad range of expression. mutations that inactivate this molecule affect primarily the development of the B-cell linea...
Topics
- Acute Disease
- Adolescent
- Adult
- Agammaglobulinaemia Tyrosine Kinase
- Aged
- Child
- DNA, Complementary
- Female
- Humans
- Leukemia, Myeloid
- Male
- Middle Aged
- Monocytes
- Mutation
- Protein-Tyrosine Kinases