Article
Expression of the X-linked agammaglobulinemia gene, btk in B-cell acute lymphoblastic leukemia.
Leukemia - 1 Apr 1994
Katz F E, Lovering R C, Bradley L A, Rigley K P, Brown D, Cotter F, Chessells J M, Levinsky R J, Kinnon C
Abstract excerpt
The gene which causes X-linked agammaglobulinemia, btk, has recently been identified as a cytoplasmic tyrosine kinase expressed almost exclusively in B cells, and at all stages of B-cell differentiation. To assess the possibility of involvement of this gene in childhood B-cell malignancies, cells...
Topics
- Adolescent
- Agammaglobulinaemia Tyrosine Kinase
- Agammaglobulinemia
- Blotting, Western
- Burkitt Lymphoma
- Child
- Child, Preschool
- Female
- Genetic Linkage
- Humans
- Infant
- Male
- Mutation
- Protein-Tyrosine Kinases
- X Chromosome