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Article

Expression of the X-linked agammaglobulinemia gene, btk in B-cell acute lymphoblastic leukemia.

Leukemia - 1 Apr 1994

Katz F E, Lovering R C, Bradley L A, Rigley K P, Brown D, Cotter F, Chessells J M, Levinsky R J, Kinnon C

Abstract excerpt

The gene which causes X-linked agammaglobulinemia, btk, has recently been identified as a cytoplasmic tyrosine kinase expressed almost exclusively in B cells, and at all stages of B-cell differentiation. To assess the possibility of involvement of this gene in childhood B-cell malignancies, cells from 23 pediatric patients with B-cell acute lymphoblastic leukemia were examined for expression and alteration of the...

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PMID: 8152253

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Expression of the X-linked agammaglobulinemia gene, btk in B-cell acute lymphoblastic leukemia.PMID 8152253Read ↗

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Expression of Bruton's tyrosine kinase protein within the B cell lineageSemantic proximity Read ↗

Identification of 22 novel BTK gene variants in B cell deficiency with hypogammaglobulinemia.Semantic proximity Read ↗

X-Linked Agammaglobulinemia A Clinical and Molecular AnalysisSemantic proximity Read ↗

Identification of Bruton's tyrosine kinase (Btk) gene mutations and characterization of the derived proteins in 35 X-linked agammaglobulinemia families: a nationwide study of Btk deficiency in Japan.Semantic proximity Read ↗

X-linked agammaglobulinemia associated with B-precursor acute lymphoblastic leukemia.Semantic proximity Read ↗

Genomic organization and structure of Bruton agammaglobulinemia tyrosine kinase: localization of mutations associated with varied clinical presentations and course in X chromosome-linked agammaglobulinemia.Semantic proximity Read ↗

Deficiency of Bruton's tyrosine kinase in B cell precursor leukemia cells.Semantic proximity Read ↗

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X-linked agammaglobulinemia (XLA): a genetic tyrosine kinase (Btk) disease.Semantic proximity Read ↗

Mutations of the Btk gene in 12 unrelated families with X-linked agammaglobulinemia in Japan.Semantic proximity Read ↗

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