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Article

Expression of Bruton's agammaglobulinemia tyrosine kinase gene, <i>BTK</i>, is selectively down-regulated in T lymphocytes and plasma cells.

1 Jan 1994

Abstract excerpt

The gene mutated in the human disease, X-linked agammaglobulinemia (XLA), is related to the Src gene family of cytoplasmic protein-tyrosine kinases and is designated Btk (Bruton's agammaglobulinemia tyrosine kinase; formerly Atk/Bpk; the human gene is denoted BTK, using capital letters according to the kinase nomenclature). We have recently reported that this gene is expressed in B lymphocytes and that the...

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PMID: 8283037
DOI: 10.4049/jimmunol.152.2.557

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Expression of Bruton's agammaglobulinemia tyrosine kinase gene, <i>BTK</i>, is selectively down-regulated in T lymphocytes and plasma cells.PMID 8283037Read ↗

Expression of Bruton's tyrosine kinase protein within the B cell lineageSemantic proximity Read ↗

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The Bruton's tyrosine kinase gene is expressed throughout B cell differentiation, from early precursor B cell stages preceding immunoglobulin gene rearrangement up to mature B cell stagesSemantic proximity Read ↗

Identification of Bruton's tyrosine kinase (Btk) gene mutations and characterization of the derived proteins in 35 X-linked agammaglobulinemia families: a nationwide study of Btk deficiency in Japan.Semantic proximity Read ↗

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X-Linked Agammaglobulinemia A Clinical and Molecular AnalysisSemantic proximity Read ↗

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