Article
Increased flexibility and selectivity in spatial learning of transgenic mice ectopically expressing the neural cell adhesion molecule L1 in astrocytes.
The European journal of neuroscience - 1 Feb 1998
Wolfer D P, Mohajeri H M, Lipp H P, Schachner M
Abstract excerpt
The expression of the neural cell adhesion molecule L1 is altered by neuronal activity and promotes neurite outgrowth in vitro. To study the effects of L1 on learning and synaptic plasticity, transgenic mice have been created which express L1 ectopically in glial fibrillary acidic protein (GFAP)...
Topics
- Animals
- Astrocytes
- Avoidance Learning
- Behavior, Animal
- Factor Analysis, Statistical
- Genotype
- Glial Fibrillary Acidic Protein
- Learning
- Leukocyte L1 Antigen Complex
- Maze Learning
- Membrane Glycoproteins
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Transgenic
- Neural Cell Adhesion Molecules
- Space Perception