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Article

Phosphorylation of Mycobacterium leprae heat-shock 70 protein at threonine 175 alters its substrate binding characteristics.

Biochimica et biophysica acta - 8 Sept 1998

Peake P, Winter N, Britton W

Abstract excerpt

We have examined the functional properties including autophosphorylation of the Mycobacterium leprae Hsp70 homologue. Recombinant M. leprae Hsp70 had pH optima for its adenosine triphosphatase and autophosphorylating activities which were near pH 8 and 6, respectively. Both these activities were...

Topics

Adenosine Triphosphatases
Aprotinin
Calcium
HSP70 Heat-Shock Proteins
Hydrogen-Ion Concentration
Mutagenesis, Site-Directed
Mutation
Mycobacterium leprae
Phosphorylation
Phosphothreonine
Protein Binding
Recombinant Proteins

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Identifiers

PMID: 9748655
DOI: 10.1016/s0167-4838(98)00156-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9748655-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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