Article
Mutational alteration of the breakage/resealing subunit of bacteriophage T4 DNA topoisomerase confers resistance to antitumor agent m-AMSA.
Molecular & general genetics : MGG - 1 Mar 1990
Huff A C, Ward R E, Kreuzer K N
Abstract excerpt
Bacteriophage T4 provides a simple model system in which to examine the mechanism of action of antitumor agents that have been proposed to attack type II DNA topoisomerases. Prior results demonstrated that T4 type II DNA topoisomerase is the target of antitumor agent 4'-(9-acridinylamino)methanesulfon-m-anisidide (m-AMSA) in phage-infected Escherichia coli: a point mutation in topoisomerase structural gene 39 was...
Topics
- Amsacrine
- DNA Topoisomerases, Type II
- DNA, Viral
- Drug Resistance, Microbial
- Genes, Viral
- Mutation
- Phenotype
- T-Phages
- Viral Structural Proteins