Polycyclic aromatic hydrocarbon-DNA adducts in human placenta and modulation by CYP1A1 induction and genotype.

doi:10.1093/carcin/19.8.1389

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Article

Polycyclic aromatic hydrocarbon-DNA adducts in human placenta and modulation by CYP1A1 induction and genotype.

Carcinogenesis - 1 Aug 1998

Whyatt R M, Bell D A, Jedrychowski W, Santella R M, Garte S J, Cosma G, Manchester D K, Young T L, Cooper T B, Ottman R, Perera F P

Abstract excerpt

This study investigated the relationship in human placenta between polycyclic aromatic hydrocabon (PAH)-DNA adduct levels and two biomarkers of cytochrome P4501A1 (CYP1A1): gene induction evidenced by CYP1A1 mRNA, and a genetic polymorphism, the CYP1A1 MspI RFLP. CYP1A1 codes for an inducible enz...

Topics

Adult
Biomarkers
Cohort Studies
Cytochrome P-450 CYP1A1
DNA Adducts
Enzyme Induction
Female
Genotype
Humans
Infant, Newborn
Placenta
Polycyclic Aromatic Hydrocarbons
Polymorphism, Restriction Fragment Length
RNA, Messenger

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Open in PubMed

Identifiers

PMID: 9744534
DOI: 10.1093/carcin/19.8.1389

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9744534-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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