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Article

S-Phase-specific Activation of PKCα Induces Senescence in Non-small Cell Lung Cancer Cells

28 Dec 2007

Abstract excerpt

Protein kinase C (PKC) has been widely implicated in positive and negative control of cell proliferation. We have recently shown that treatment of non-small cell lung cancer (NSCLC) cells with phorbol 12-myristate 13-acetate (PMA) during G1 phase inhibits the progression into S phase, an effect mediated by PKCδ-induced up-regulation of the cell cycle inhibitor p21Cip1. However, PMA treatment in asynchronously...

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PMID: 18162471
DOI: 10.1074/jbc.m707576200

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