Article
Novel antineoplastic agents with efficacy against multidrug resistant tumor cells.
Bioorganic & medicinal chemistry letters - 6 Oct 1998
Medina J C, Shan B, Beckmann H, Farrell R P, Clark D L, Learned R M, Roche D, Li A, Baichwal V, Case C, Baeuerle P A, Rosen T, Jaen J C
Abstract excerpt
A novel series of pentafluorobenzenesulfonamides has been shown to inhibit the growth of a variety of human tumor cell lines. Among the cell types against which these agents were evaluated were the multidrug resistant (MDR) cell lines MCF-7/ADR and P388/ADR. The cytotoxic activity of members of this series of compounds was not affected by the multidrug resistant pump in MCF-7/ADR or P388/ADR cells.
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