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Article

Genes encoding ribosomal proteins Rps0A/B of Saccharomyces cerevisiae interact with TOM1 mutants defective in ribosome synthesis.

Genetics - 1 Mar 2001

Tabb A L, Utsugi T, Wooten-Kee C R, Sasaki T, Edling S A, Gump W, Kikuchi Y, Ellis S R

Abstract excerpt

The Saccharomyces cerevisiae RPS0A/B genes encode proteins of the 40S ribosomal subunit that are required for the maturation of 18S rRNA. We show here that the RPS0 genes interact genetically with TOM1. TOM1 encodes a member of the hect-domain-containing E3 ubiquitin-protein ligase family that is required for growth at elevated temperatures. Mutant alleles of the RPS0 and TOM1 genes have synergistic effects on...

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Identifiers

PMID: 11238398
DOI: 10.1093/genetics/157.3.1107
PMCID: PMC1461576

Genes

TOM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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