Article
Effects of transition metals on nitric oxide synthase catalysis.
Proceedings of the National Academy of Sciences of the United States of America - 15 Sept 1998
Perry J M, Marletta M A
Abstract excerpt
The biosynthesis of nitric oxide (NO) by the enzyme NO synthase (NOS) proceeds by the hydroxylation of L-arginine to form NG-hydroxy-L-arginine followed by the conversion of NG-hydroxy-L-arginine to L-citrulline and NO. The previously identified requirements of this relatively complicated reactio...
Topics
- Animals
- Binding Sites
- Biopterins
- Cations, Divalent
- Iron
- Metals
- Mixed Function Oxygenases
- Mutation
- Nitric Oxide Synthase
- Nitric Oxide Synthase Type II
- Protein Binding
- Rats
- Spectrophotometry