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Article

Effects of transition metals on nitric oxide synthase catalysis.

Proceedings of the National Academy of Sciences of the United States of America - 15 Sept 1998

Perry J M, Marletta M A

Abstract excerpt

The biosynthesis of nitric oxide (NO) by the enzyme NO synthase (NOS) proceeds by the hydroxylation of L-arginine to form NG-hydroxy-L-arginine followed by the conversion of NG-hydroxy-L-arginine to L-citrulline and NO. The previously identified requirements of this relatively complicated reaction include several protein-bound cofactors: cytochrome P450-type heme, flavin mononucleotide (FMN), flavin adenine...

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Identifiers

PMID: 9736696
DOI: 10.1073/pnas.95.19.11101
PMCID: PMC21602

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