Article
Tetrahydrobiopterin redox cycling in nitric oxide synthase: evidence supports a through-heme electron delivery.
The FEBS journal - 1 Dec 2016
Ramasamy Somasundaram, Haque Mohammad Mahfuzul, Gangoda Mahinda, Stuehr Dennis J
Abstract excerpt
The nitric oxide synthases (NOS) catalyze a two-step oxidation of l-arginine (Arg) to generate NO. In the first step, O2 activation involves one electron being provided to the heme by an enzyme-bound 6R-tetrahydro-l-biopterin cofactor (H4 B), and the H4 B radical must be reduced back to H4 B in order for NOS to continue catalysis. Although an NADPH-derived electron is used to reduce the H4 B radical, how this...
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