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Article

Mutation in the flavin mononucleotide domain modulates magnetic circular dichroism spectra of the iNOS ferric cyano complex in a substrate-specific manner.

Inorganic chemistry - 1 Aug 2011

Sempombe Joseph, Galinato Mary Grace I, Elmore Bradley O, Fan Weihong, Guillemette J Guy, Lehnert Nicolai, Kirk Martin L, Feng Changjian

Abstract excerpt

We have obtained low-temperature magnetic circular dichroism (MCD) spectra for ferric cyano complexes of the wild type and E546N mutant of a human inducible nitric oxide synthase (iNOS) oxygenase/flavin mononucleotide (oxyFMN) construct. The mutation at the FMN domain has previously been shown to modulate the MCD spectra of the l-arginine-bound ferric iNOS heme (Sempombe, J.; et al. J. Am. Chem. Soc. 2009, 131,...

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Identifiers

PMID: 21718007
DOI: 10.1021/ic200952c
PMCID: PMC3143224

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Source receipt: pubmed, retrieved 7 Sept 2026.

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