Anthracene-9,10-diones as potential anticancer agents: bacterial mutation studies of amido-substituted derivatives reveal an unexpected lack of mutagenicity.

Abstract excerpt

Fifteen anthracene-9,10-dione ("anthraquinone") derivatives with (omega-aminoalkyl)carboxamido substituents at the 1-, 2-, 1,4-, or 2, 6-ring positions were tested for bacterial mutagenicity in reverse-mutation assays using Salmonella typhimurium frameshift strains TA1538, TA98, and TA97a, in the presence and absence of a metabolic activation system prepared from the livers of rats treated with Aroclor 1254. Six...

Topics

• Animals
• Anthracenes
• Antibiotics, Antineoplastic
• Antineoplastic Agents
• Escherichia coli
• Male
• Mitoxantrone
• Mutagens
• Mutation
• Rats
• Salmonella typhimurium