Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genotoxicity assessment of new synthesized acridine derivative--3,6-diamino-10-methyl-9,10-dihydroacridine.

Mutation research - 18 Aug 1999

Ferenc T, Janik-Spiechowicz E, Bratkowska W, Lopaczyńska D, Strózyński H, Denys A, Mordalska A

Abstract excerpt

A new synthesized acridine derivative, 3,6-diamino-10-methyl-9, 10-dihydroacridine (AcrH), was tested for in vitro reverse mutations with Salmonella TA strains, chromosome aberrations and sister chromatid exchanges (SCE) in human lymphocytes, and for in vivo chromosome aberrations in bone marrow of mice. Using the classic plate incorporation method, mutagenicity of AcrH in bacterial cells (TA97a, TA98, TA100 and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Aberrations
Share to Mice

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Inbred BALB C

Share to Mutagens

Share to Rats, Wistar

Share to Salmonella typhimurium

Share to Sister Chromatid Exchange

Source

Identifiers

PMID: 10521686
DOI: 10.1016/s1383-5718(99)00112-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genotoxicity assessment of new synthesized acridine derivative--3,6-diamino-10-methyl-9,10-dihydroacridine.PMID 10521686Read ↗

Evaluation of new 2,2'-dimethyl-5,5'-dipropoxybenzidine- and 3,3'-dipropoxybenzidine-based direct dye analogs for mutagenic activity by use of the Salmonella/mammalian mutagenicity assay.Semantic proximity Read ↗

Comparative evaluation of three methylene dianiline isomers in the bacterial reverse mutation assay, the in vitro gene mutation test, and the in vitro chromosomal aberration test.Semantic proximity Read ↗

Evaluation of 5-aminoisoquinoline (5-AIQ), a novel PARP-1 inhibitor for genotoxicity potential in vitro and in vivo.Semantic proximity Read ↗

Antigenotoxic properties of two newly synthesized β-aminoketones against N-methyl-N'-nitro-N-nitrosoguanidine and 9-aminoacridine-induced mutagenesis.Semantic proximity Read ↗

Mutagenicity evaluation of Anastatica hierochuntica L. aqueous extract in vitro and in vivo.Semantic proximity Read ↗

Mutagenic and antimutagenic effects of acridinium salts in yeast.Semantic proximity Read ↗

In vivo antigenotoxic potential and possible mechanism of action of selected 4-hydroxy-2H-chromen-2-one derivatives.Semantic proximity Read ↗

Gene mutation assay of acrolein in the CHO/HGPRT test system.Semantic proximity Read ↗

Genotoxicity test battery - An assessment of its utility in early drug development.Semantic proximity Read ↗

Evaluation of genotoxicity of multi-walled carbon nanotubes in a battery of in vitro and in vivo assays.Semantic proximity Read ↗

Genotoxicity of 2,6- and 3,5-dimethylaniline in cultured mammalian cells: the role of reactive oxygen species.Semantic proximity Read ↗

Evaluation of the genotoxicity of extracts of Houttuynia cordata Thunb.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.