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Article

Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase.

Nature genetics - 1 Jan 1998

Jenne D E, Reimann H, Nezu J, Friedel W, Loff S, Jeschke R, Müller O, Back W, Zimmer M

Abstract excerpt

Peutz-Jeghers (PJ) syndrome is an autosomal-dominant disorder characterized by melanocytic macules of the lips, multiple gastrointestinal hamartomatous polyps and an increased risk for various neoplasms, including gastrointestinal cancer. The PJ gene was recently mapped to chromosome 19p13.3 by l...

Read the complete abstract on PubMed

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Source

Identifiers

PMID: 9425897
DOI: 10.1038/ng0198-38

Genes

STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-9425897-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase.PMID 9425897Read ↗

A novel mutation in STK11 gene is associated with Peutz-Jeghers syndrome in Chinese patients.Semantic proximity Read ↗

A 23-Nucleotide Deletion in STK11 Gene Causes Peutz-Jeghers Syndrome and Malignancy in a Chinese Patient Without a Positive Family History.Semantic proximity Read ↗

A novel missense mutation of the STK11 gene in a Chinese family with Peutz-Jeghers syndrome.Semantic proximity Read ↗

A novel de novo mutation in the serine-threonine kinase STK11 gene in a Korean patient with Peutz-Jeghers syndrome.Semantic proximity Read ↗

Haploinsufficiency of STK11 and neighboring genes cause a contiguous gene syndrome including Peutz-Jeghers phenotype.Semantic proximity Read ↗

STK11/LKB1 germline mutations are not identified in most Peutz-Jeghers syndrome patients.Semantic proximity Read ↗

Large deletions and splicing-site mutations in the STK11 gene in Peutz-Jeghers Chilean families.Semantic proximity Read ↗

A novel mutation in STK11 gene is associated with Peutz-Jeghers Syndrome in Indian patients.Semantic proximity Read ↗

Role of the Serine/Threonine Kinase 11 (STK11) or Liver Kinase B1 (LKB1) Gene in Peutz-Jeghers Syndrome.Semantic proximity Read ↗

An exploration of genotype-phenotype link between Peutz-Jeghers syndrome and STK11: a review.Semantic proximity Read ↗

Two cases of somatic STK11 mosaicism in Danish patients with Peutz-Jeghers syndrome.Semantic proximity Read ↗

Clinical and Molecular Analysis in Patients with Peutz-Jeghers Syndrome.Semantic proximity Read ↗

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