Gonococcal invasion of epithelial cells driven by P.IA, a bacterial ion channel with GTP binding properties.

doi:10.1084/jem.188.5.941

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Article

Gonococcal invasion of epithelial cells driven by P.IA, a bacterial ion channel with GTP binding properties.

The Journal of experimental medicine - 7 Sept 1998

van Putten J P, Duensing T D, Carlson J

Abstract excerpt

The neisserial porin P.I is a GTP binding protein that forms a voltage-gated channel that translocates into mammalian cell membranes and modulates host cell signaling events. Here, we report that P.I confers invasion of the bacterial pathogen Neisseria gonorrhoeae into Chang epithelial cells and...

Topics

Alleles
Antigens, Bacterial
Bacterial Outer Membrane Proteins
Cell Line
Epithelial Cells
GTP-Binding Proteins
Humans
Ion Channels
Mutagenesis, Insertional
Neisseria gonorrhoeae
Phosphates
Porins

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