Article
Isolation of Neisseria gonorrhoeae mutants that show enhanced trafficking across polarized T84 epithelial monolayers.
Infection and immunity - 1 Feb 2000
Hopper S, Wilbur J S, Vasquez B L, Larson J, Clary S, Mehr I J, Seifert H S, So M
Abstract excerpt
Initiation of a gonococcal infection involves attachment of Neisseria gonorrhoeae to the plasma membrane of an epithelial cell in the mucosal epithelium and its internalization, transepithelial trafficking, and exocytosis from the basal membrane. Piliation and expression of certain Opa proteins and the immunoglobulin A1 protease influence the transcytosis process. We are interested in identifying other genetic...
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