The homeotic gene lin-39 and the evolution of nematode epidermal cell fates.

doi:10.1126/science.278.5337.452

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Article

The homeotic gene lin-39 and the evolution of nematode epidermal cell fates.

Science (New York, N.Y.) - 17 Oct 1997

Eizinger A, Sommer R J

Abstract excerpt

The fate of ventral epidermal cells differs among nematode species. Nonvulval cells fuse with the epidermis in Caenorhabditis elegans, whereas the homologous cells undergo apoptosis in Pristionchus pacificus. The homeotic gene lin-39 is involved in the regulation of these epidermal cell fates. In Caenorhabditis, lin-39 prevents cell fusion of potential vulval cells and specifies the vulva equivalence group....

Topics

Amino Acid Sequence
Animals
Apoptosis
Base Sequence
Biological Evolution
Caenorhabditis elegans
Cell Fusion
Cell Lineage
Epidermal Cells
Exons
Female
Genes, Helminth

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Homeobox

Molecular Sequence Data

Mutation

Phenotype

Rhabditida

Stem Cells

Source

Open in PubMed

Identifiers

PMID: 9334302
DOI: 10.1126/science.278.5337.452

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-9334302-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The homeotic gene lin-39 and the evolution of nematode epidermal cell fates.PMID 9334302Read ↗

The Pristionchus HOX gene Ppa-lin-39 inhibits programmed cell death to specify the vulva equivalence group and is not required during vulval induction.Semantic proximity Read ↗

Apoptosis and change of competence limit the size of the vulva equivalence group in Pristionchus pacificus: a genetic analysis.Semantic proximity Read ↗

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