Testing for contributions of mitochondrial DNA mutations to complex diseases.

doi:10.1002/(SICI)1098-2272(1998)15:5<451::AID-GEPI2>3.0.CO;2-3

Back to search

Article

Testing for contributions of mitochondrial DNA mutations to complex diseases.

Genetic epidemiology - 1 Jan 1998

Sun F, Ashley-Koch A E, Durham L K, Feingold E, Halloran M E, Manatunga A K, Sherman S L

Abstract excerpt

Several complex disorders are suspected of being associated with mitochondrial DNA (mtDNA) mutations. We studied the statistical properties of a test based on proband-relative pairs to identify potential mtDNA mutation involvement in a complex disorder. The test compares the recurrence risk of re...

Topics

DNA, Mitochondrial
Epidemiologic Methods
Female
Genetic Diseases, Inborn
Humans
Male
Models, Genetic
Mutation
Pedigree

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.