Article
Involvement of activator protein-1 (AP-1) in induction of apoptosis by vitamin E succinate in human breast cancer cells.
Molecular carcinogenesis - 1 Jul 1997
Zhao B, Yu W, Qian M, Simmons-Menchaca M, Brown P, Birrer M J, Sanders B G, Kline K
Abstract excerpt
The purpose of this study was to document induction of apoptosis by vitamin E succinate (VES; RRR-alpha-tocopheryl succinate) in human breast cancer cells in culture and to characterize potential c-jun involvement. VES at 18.8 microM (10 micrograms/mL) induced DNA synthesis arrest, reduced total...
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