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Article

Connexin32-null mice develop demyelinating peripheral neuropathy

1 Sept 1998

Abstract excerpt

Mutations in the gene encoding the gap junction protein connexin32 (Cx32) cause X-linked Charcot-Marie-Tooth disease (CMTX), a common form of inherited demyelinating peripheral neuropathy. To learn more about the pathogenesis of CMTX, we examined the PNS and CNS of cx32-null mice (cx32-/Y males and cx32-/-females) by light and electron microscopy. These mice develop a progressive demyelinating peripheral...

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PMID: 9700485
DOI: 10.1002/(sici)1098-1136(199809)24:1<8::aid-glia2>3.0.co;2-3

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