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Article

Transgenic expression of human connexin32 in myelinating Schwann cells prevents demyelination in connexin32-null mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 9 Feb 2005

Scherer Steven S, Xu Yi-Tian, Messing Albee, Willecke Klaus, Fischbeck Kenneth H, Jeng Linda Jo Bone

Abstract excerpt

Mutations in Gap Junction beta1 (GJB1), the gene encoding the gap junction protein connexin32 (Cx32), cause the X-linked form of Charcot-Marie-Tooth disease (CMT1X), an inherited demyelinating neuropathy. We investigated the possibility that the expression of mutant Cx32 in other cells besides myelinating Schwann cells contributes to the development of demyelination. Human Cx32 was expressed in transgenic mice...

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Identifiers

PMID: 15703409
DOI: 10.1523/JNEUROSCI.3082-04.2005
PMCID: PMC6725992

Genes

GJB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Transgenic expression of human connexin32 in myelinating Schwann cells prevents demyelination in connexin32-null mice.PMID 15703409Read ↗

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