Article
The panE gene, encoding ketopantoate reductase, maps at 10 minutes and is allelic to apbA in Salmonella typhimurium.
Journal of bacteriology - 1 Sept 1998
Frodyma M E, Downs D
Abstract excerpt
In Salmonella typhimurium, precursors to the pyrimidine moiety of thiamine are synthesized de novo by the purine biosynthetic pathway or the alternative pyrimidine biosynthetic (APB) pathway. The apbA gene was the first locus defined as required for function of the APB pathway (D. M. Downs and L. Petersen, J. Bacteriol. 176:4858-4864, 1994). Recent work showed the ApbA protein catalyzes the NADPH-specific...
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